ALDH2 protects naturally aged mouse retina <i>via</i> inhibiting oxidative stress-related apoptosis and enhancing unfolded protein response in endoplasmic reticulum

Pan Long; Mengshan He; Weiming Yan; Wei Chen; Dongyu Wei; Siwang Wang; Zuoming Zhang; Wei Ge; Tao Chen

doi:doi:10.18632/aging.202325

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Research Paper Volume 13, Issue 2 pp 2750—2767

ALDH2 protects naturally aged mouse retina via inhibiting oxidative stress-related apoptosis and enhancing unfolded protein response in endoplasmic reticulum

Figure 7. The expression of retinal TNF-α, IL-6 and IL-1 in aged ALDH2 overexpression and aged Alda1-treated mice. (A) The expression of retinal TNF-α in aged ALDH2 overexpression mice; (B) The expression of retinal IL-6 in aged ALDH2 overexpression mice; (C) The expression of retinal IL-1 in aged ALDH2 overexpression mice; (D) The expression of retinal TNF-α in aged Alda1-treated mice; (E) The expression of retinal IL-6 in aged Alda1-treated mice; (F) The expression of retinal IL-1 in aged Alda1-treated mice. All analyses were performed in duplicate. Values are presented as the mean ± SD, n = 4 mice per group. *P<0.05: aged (WT) and aged (ALDH2+) vs young (WT) or Aged (DMSO) and aged (Alda1) vs young; ^#P<0.05: aged (ALDH2+) vs aged (WT) or aged (Alda1) vs aged (DMSO).