Research Paper Volume 13, Issue 2 pp 2780—2802

Identification of a novel immune microenvironment signature predicting survival and therapeutic options for bladder cancer

Enrichment analysis of cancer and glycolysis related pathways associated with risk score in TCGA-BLCA database. (A) Gene set enrichment analysis (GSEA) on the association of risk score with adherens junction, focal adhesion, cell cycle and DNA replication. (B) Risk score of UBC patients with disease free and progression/recurrence in TCGA-BLCA dataset. (C) GSEA plots depicting enrichment of glycolysis pathways and risk score. (D) The correlation between the expression of glycolytic genes and the risk score. (E) The identified core candidate genes (red) involved in enzymatic glycolysis are shown. (F) The representative IHC images of ki-67 expression in UBC tissues with low- or high-risk.

Figure 11. Enrichment analysis of cancer and glycolysis related pathways associated with risk score in TCGA-BLCA database. (A) Gene set enrichment analysis (GSEA) on the association of risk score with adherens junction, focal adhesion, cell cycle and DNA replication. (B) Risk score of UBC patients with disease free and progression/recurrence in TCGA-BLCA dataset. (C) GSEA plots depicting enrichment of glycolysis pathways and risk score. (D) The correlation between the expression of glycolytic genes and the risk score. (E) The identified core candidate genes (red) involved in enzymatic glycolysis are shown. (F) The representative IHC images of ki-67 expression in UBC tissues with low- or high-risk.