Research Paper Volume 13, Issue 2 pp 2803—2821

SPC25 overexpression promotes tumor proliferation and is prognostic of poor survival in hepatocellular carcinoma

SPC25 expression in normal human tissue, human tumors, and in HCC. (A) SPC25 mRNA expression in normal human tissues. GTEx: The Genotype-Tissue Expression project; FPKM: Fragments Per Kilobase per Million. (B) SPC25 mRNA expression in multiple human cancers is higher compared to corresponding normal tissues. RPKM: Reads Per Kilobase per Million. (C) SPC25 mRNA is significantly overexpressed in HCC samples compared to normal controls, according to UALCAN. (D) Both male and female HCC patients showed a higher SPC25 transcriptional level than normal controls, according to UALCAN. (E) UALCAN analysis showed that SPC25 mRNA levels are significantly higher among Caucasian, African-American, and Asian HCC patients than normal controls. Besides, SPC25 showed a relatively higher transcriptional level in Asian patients in contrast with Caucasian patients. (F) SPC25 mRNA expression in Asians HCC patients is significantly higher than that in the Caucasian HCC patients based on TCGA HCC samples screened by race. (G) SPC25 mRNA is significantly overexpressed in Chinese HCC tumor specimens vs. corresponding adjacent normal liver tissue. (H) Representative images of SPC25 protein expression in normal liver and HCC samples from Chinese patients. (*P

Figure 1. SPC25 expression in normal human tissue, human tumors, and in HCC. (A) SPC25 mRNA expression in normal human tissues. GTEx: The Genotype-Tissue Expression project; FPKM: Fragments Per Kilobase per Million. (B) SPC25 mRNA expression in multiple human cancers is higher compared to corresponding normal tissues. RPKM: Reads Per Kilobase per Million. (C) SPC25 mRNA is significantly overexpressed in HCC samples compared to normal controls, according to UALCAN. (D) Both male and female HCC patients showed a higher SPC25 transcriptional level than normal controls, according to UALCAN. (E) UALCAN analysis showed that SPC25 mRNA levels are significantly higher among Caucasian, African-American, and Asian HCC patients than normal controls. Besides, SPC25 showed a relatively higher transcriptional level in Asian patients in contrast with Caucasian patients. (F) SPC25 mRNA expression in Asians HCC patients is significantly higher than that in the Caucasian HCC patients based on TCGA HCC samples screened by race. (G) SPC25 mRNA is significantly overexpressed in Chinese HCC tumor specimens vs. corresponding adjacent normal liver tissue. (H) Representative images of SPC25 protein expression in normal liver and HCC samples from Chinese patients. (*P < 0.05, **P < 0.01, ***P < 0.001).