Research Paper Volume 13, Issue 2 pp 2864—2884

The long intergenic noncoding RNA GAS5 reduces cisplatin-resistance in non-small cell lung cancer through the miR-217/LHPP axis

Upregulation of GAS5 inhibits cisplatin-resistant NSCLC cell cloning ability and migration. (A) Colony formation assays in A549/DDP and H1299/DDP cells transduced with pcDNA-NC, pcDNA-GAS5 or pcDNA-GAS5 + pPG-miR-217 were presented. (B) Wound healing assays in H1299/DDP cells transduced with pcDNA-NC, pcDNA-GAS5 or pcDNA-GAS5 + pPG-miR-217 were presented. *p

Figure 7. Upregulation of GAS5 inhibits cisplatin-resistant NSCLC cell cloning ability and migration. (A) Colony formation assays in A549/DDP and H1299/DDP cells transduced with pcDNA-NC, pcDNA-GAS5 or pcDNA-GAS5 + pPG-miR-217 were presented. (B) Wound healing assays in H1299/DDP cells transduced with pcDNA-NC, pcDNA-GAS5 or pcDNA-GAS5 + pPG-miR-217 were presented. *p < 0.05, **p < 0.01, ***p < 0.001. Colony formation assays were performed at least three times.