Research Paper Volume 13, Issue 2 pp 2864—2884

The long intergenic noncoding RNA GAS5 reduces cisplatin-resistance in non-small cell lung cancer through the miR-217/LHPP axis

A model to show the relation between GAS5, miR-217 and LHPP. GAS5 inhibited NSCLC cisplatin-resistance, metastasis and EMT progression by acting as a miRNA sponge to impair the endogenous effects of miR-217, thereby promoting mRNA and protein expression of LHPP.

Figure 9. A model to show the relation between GAS5, miR-217 and LHPP. GAS5 inhibited NSCLC cisplatin-resistance, metastasis and EMT progression by acting as a miRNA sponge to impair the endogenous effects of miR-217, thereby promoting mRNA and protein expression of LHPP.