Research Paper Volume 13, Issue 3 pp 3898—3908

Intranasal treatment of lixisenatide attenuated emotional and olfactory symptoms via CREB-mediated adult neurogenesis in mouse depression model

Intranasal treatment of LXT reserved CUMS induced emotional and olfactory dysfunctions. (A) Schematic picture to show the experimental process. Mice were performed with CUMS protocol and conducted with the intranasal administration of the LXT. (B, C) Immobility time of the mice to show the antidepressant behaviors in FST and TST. (D) Time of the mice to spend in center area of the region in open field test. (E) Time of mouse to spend in open arm in elevated plus maze test. (F, G) Duration of the sniff and the separation index (sniff duration of pentanol) of mice in olfactory discrimination test.

Figure 1. Intranasal treatment of LXT reserved CUMS induced emotional and olfactory dysfunctions. (A) Schematic picture to show the experimental process. Mice were performed with CUMS protocol and conducted with the intranasal administration of the LXT. (B, C) Immobility time of the mice to show the antidepressant behaviors in FST and TST. (D) Time of the mice to spend in center area of the region in open field test. (E) Time of mouse to spend in open arm in elevated plus maze test. (F, G) Duration of the sniff and the separation index (sniff duration of pentanol) of mice in olfactory discrimination test.