Hippocampal neurogenesis is required in effects of LXT to CUMS model. (A) Schematic picture to show the experimental process. Mice with CUMS protocol was conducted with TMZ treatment and combined with the intranasal administration of the LXT. (B) Confocal image to show the distribution and cell number of DCX+ immature neurons (Red). (C, D) Statistical analysis of DCX+ immature neurons and DCX+ neural fibers. (E, F) Statistical analysis of immobility time in FST as well as the time spend in center region in open field test.