Research Paper Volume 13, Issue 3 pp 3969—3993

Transcriptomic characterization reveals prognostic molecular signatures of sorafenib resistance in hepatocellular carcinoma


Figure 3. PPI network and the most significant module of DEGs. (A) The PPI network of DEGs was constructed based on database STRING and Cytoscape software. (B) The most significant module was obtained from the PPI network by MCODE with criteria as follows: MCODE scores > 5, degree cut-off = 2, node score cut-off= 0.2, node density cut-off=0.1, Max depth=100 and k-score = 2. PPI, protein-protein interaction; DEGs, differentially expressed genes; MCODE, Molecular Complex Detection (version 1.6), an APP of Cytoscape for clustering a given network based on the topology to find densely connected regions.