Research Paper Volume 13, Issue 3 pp 3969—3993

Transcriptomic characterization reveals prognostic molecular signatures of sorafenib resistance in hepatocellular carcinoma

Effect of selected genes on the cytotoxicity of sorafenib. Experimental verification of the relationship between the selected genes and sorafenib resistance in vitro. (A) Transcriptional expression of four selected genes in Huh7 cells compared to LO2. With transfection with siRNA or lncRNA smart silencer, the treated Huh7 cells were exposed to sorafenib, and cell proliferation and invasion were detected 48 hours later. (B, C) The effects of sorafenib on Huh7 proliferation and invasion after RNA interference. **p

Figure 9. Effect of selected genes on the cytotoxicity of sorafenib. Experimental verification of the relationship between the selected genes and sorafenib resistance in vitro. (A) Transcriptional expression of four selected genes in Huh7 cells compared to LO2. With transfection with siRNA or lncRNA smart silencer, the treated Huh7 cells were exposed to sorafenib, and cell proliferation and invasion were detected 48 hours later. (B, C) The effects of sorafenib on Huh7 proliferation and invasion after RNA interference. **p<0.01, ****p<0.0001.