Research Paper Volume 13, Issue 2 pp 2885—2894

Serum response factor, a novel early diagnostic biomarker of acute kidney injury

Analysis of the microarray results from bilateral I/R mice. (A, B) Gene expression profiling of kidney at 2 h and 4 h after I/R compared with the control group. Volcano plot of log2 fold changes versus -log10 FDR showed transcriptional differences between the I/R group and the control group. Vertical dashed lines denote the cutoff of 2-fold change, and the horizontal dashed line represents the 0.05 FDR cutoff. SRF was increased after 2 h renal I/R in mice (fold change>2, FDRC) SRF expression in I/R kidneys at 2 h, 4 h, 24 h, 48 h, 72 h, 7 d, 14 d, 28 d, 6 m and 12 m. Data are expressed as the mean ± SE. *FDR

Figure 1. Analysis of the microarray results from bilateral I/R mice. (A, B) Gene expression profiling of kidney at 2 h and 4 h after I/R compared with the control group. Volcano plot of log2 fold changes versus -log10 FDR showed transcriptional differences between the I/R group and the control group. Vertical dashed lines denote the cutoff of 2-fold change, and the horizontal dashed line represents the 0.05 FDR cutoff. SRF was increased after 2 h renal I/R in mice (fold change>2, FDR<0.05). (C) SRF expression in I/R kidneys at 2 h, 4 h, 24 h, 48 h, 72 h, 7 d, 14 d, 28 d, 6 m and 12 m. Data are expressed as the mean ± SE. *FDR<0.05 (linear models for microarray analysis) versus the control group.