Research Paper Volume 13, Issue 2 pp 1633—1648

The effects of early-life growth hormone intervention on tissue specific histone H3 modifications in long-lived Ames dwarf mice

Hepatic histone H3 acetylation changes in Ames dwarf mice upon early-life GH intervention. (A, C) Representative western blots in Ames dwarf males (A) and females (C) mice upon early-life GH intervention. (B, D) Quantification of acetylation of histone H3 in males (B) and females (D). Protein quantification data (means ± SEM) are normalized to histone H3 and expressed as fold change compared with WT control (defined as 1.0), n=6 mice for each group. Data are means ± SEM. * p p

Figure 3. Hepatic histone H3 acetylation changes in Ames dwarf mice upon early-life GH intervention. (A, C) Representative western blots in Ames dwarf males (A) and females (C) mice upon early-life GH intervention. (B, D) Quantification of acetylation of histone H3 in males (B) and females (D). Protein quantification data (means ± SEM) are normalized to histone H3 and expressed as fold change compared with WT control (defined as 1.0), n=6 mice for each group. Data are means ± SEM. * p < 0.05, ** p < 0.01 by one-way ANOVA.