Research Paper Volume 13, Issue 2 pp 3031—3044

Triptolide improves neurobehavioral functions, inflammation, and oxidative stress in rats under deep hypothermic circulatory arrest

TPL inhibited DHCA induced inflammatory response in rats. On day 7 post operation, rats were euthanized and collected plasma and brain tissues to detect the inflammatory cytokines levels. The levels of brain TNFα (A), IL-1β (B), IL-6 (C) were decreased with TPL treatment after DHCA. In line with the results of brain, TPL treatment reduced the elevation of TNF-α (D), IL-1β (E) and IL-6 (F) levels in plasma after DHCA. Values were presented as x¯±s (n = 10). A difference with P

Figure 2. TPL inhibited DHCA induced inflammatory response in rats. On day 7 post operation, rats were euthanized and collected plasma and brain tissues to detect the inflammatory cytokines levels. The levels of brain TNFα (A), IL-1β (B), IL-6 (C) were decreased with TPL treatment after DHCA. In line with the results of brain, TPL treatment reduced the elevation of TNF-α (D), IL-1β (E) and IL-6 (F) levels in plasma after DHCA. Values were presented as x¯±s (n = 10). A difference with P < 0.05 was indicated statically significant. One-way ANOVA followed by Bonferroni's multiple comparison tests was performed to analyze differences between groups.