Research Paper Volume 13, Issue 2 pp 3031—3044

Triptolide improves neurobehavioral functions, inflammation, and oxidative stress in rats under deep hypothermic circulatory arrest

TPL inhibited DHCA induced oxidative stress in rats. On day 7 post operation, rats were euthanized and collected plasma and brain tissues to evaluate oxidative stress. The levels of brain MDA (A) and ROS production (B) were decreased with TPL treatment after DHCA. The activity of brain SOD (C) and GSH (D) was increased with TPL treatment after DHCA. Meanwhile, TPL treatment reduced plasma MDA (E) and ROS production (F) levels and increased the activities of SOD (G) and GSH (H) after DHCA. Values were presented as x¯±s (n = 10). Values were presented as x¯±s (n = 10). A difference with P

Figure 3. TPL inhibited DHCA induced oxidative stress in rats. On day 7 post operation, rats were euthanized and collected plasma and brain tissues to evaluate oxidative stress. The levels of brain MDA (A) and ROS production (B) were decreased with TPL treatment after DHCA. The activity of brain SOD (C) and GSH (D) was increased with TPL treatment after DHCA. Meanwhile, TPL treatment reduced plasma MDA (E) and ROS production (F) levels and increased the activities of SOD (G) and GSH (H) after DHCA. Values were presented as x¯±s (n = 10). Values were presented as x¯±s (n = 10). A difference with P < 0.05 was indicated statically significant. One-way ANOVA followed by Bonferroni's multiple comparison tests was performed to analyze differences between groups.