Review Volume 13, Issue 1 pp 1528—1564

Function of Deptor and its roles in hematological malignancies

Structure of Deptor. Schematic representation of Deptor and his two DEP domains are indicated as well PDZ domain. Degron motif and phosphorylation residues are indicated. phosphorylation at 15 different residues (T and S) located between the DEP2 and PDZ domain junction and comprising between residues T241-S299, which was determined by spectrometric studies, are also indicated.

Figure 1. Structure of Deptor. Schematic representation of Deptor and his two DEP domains are indicated as well PDZ domain. Degron motif and phosphorylation residues are indicated. phosphorylation at 15 different residues (T and S) located between the DEP2 and PDZ domain junction and comprising between residues T241-S299, which was determined by spectrometric studies, are also indicated.