Research Paper Volume 13, Issue 2 pp 3101—3111

Sleep deprivation aggravates brain injury after experimental subarachnoid hemorrhage via TLR4-MyD88 pathway

Sleep deprivation worsens SAH-induced neurological dysfunction. (A) Neurological score assay shows that sleep deprivation aggravated neurological impairment induced by SAH. (B–D) MWM assay (B) and quantification (C, D) show that sleep deprivation increased escape latencies (C) and swimming distance (D) over 4 days. The data was represented as means ± SEM. #p *p

Figure 2. Sleep deprivation worsens SAH-induced neurological dysfunction. (A) Neurological score assay shows that sleep deprivation aggravated neurological impairment induced by SAH. (BD) MWM assay (B) and quantification (C, D) show that sleep deprivation increased escape latencies (C) and swimming distance (D) over 4 days. The data was represented as means ± SEM. #p < 0.05 vs. Sham group and *p < 0.05 vs. SAH group.