Research Paper Volume 13, Issue 4 pp 5875—5891

Blockade of Indoleamine 2, 3-dioxygenase 1 ameliorates hippocampal neurogenesis and BOLD-fMRI signals in chronic stress precipitated depression

IDO1 genetic ablation reduced the depression-like phenotypes in mice under CUMS treatment. (A) Gene identification. (B) The body weight change of mice during CUMS procedure, *p#p C) the sucrose consumption test, (D) tail suspension assay, (E) forced swim assay and (F, G) open field test in WT and Ido1-/- mice. (H, I) Immunofluorescence analysis of the BDNF protein (green) expression in the hippocampus of WT and Ido1-/-groups. Bars represent mean±SEM. *ppp

Figure 4. IDO1 genetic ablation reduced the depression-like phenotypes in mice under CUMS treatment. (A) Gene identification. (B) The body weight change of mice during CUMS procedure, *p< 0.05 vs. WT control group; #p < 0.05 vs. WT CUMS group. The behavior analysis by (C) the sucrose consumption test, (D) tail suspension assay, (E) forced swim assay and (F, G) open field test in WT and Ido1-/- mice. (H, I) Immunofluorescence analysis of the BDNF protein (green) expression in the hippocampus of WT and Ido1-/-groups. Bars represent mean±SEM. *p< 0.05, ** p< 0.01, *** p< 0.001.