Research Paper Volume 13, Issue 4 pp 5875—5891

Blockade of Indoleamine 2, 3-dioxygenase 1 ameliorates hippocampal neurogenesis and BOLD-fMRI signals in chronic stress precipitated depression

IDO1 genetic ablation ameliorates neurogenesis in mice under CUMS treatment. (A, C) Immunostaining and the relative fluorescence intensity of the DCX in the hippocampus of WT and Ido1-/-groups. (B, D) Immunostaining and the relative fluorescence intensity of the Nestin in the hippocampus of WT and Ido1-/-groups. (scale bar 100 μm). n = 6 mice/group. Bars represent mean±SEM. * pp

Figure 6. IDO1 genetic ablation ameliorates neurogenesis in mice under CUMS treatment. (A, C) Immunostaining and the relative fluorescence intensity of the DCX in the hippocampus of WT and Ido1-/-groups. (B, D) Immunostaining and the relative fluorescence intensity of the Nestin in the hippocampus of WT and Ido1-/-groups. (scale bar 100 μm). n = 6 mice/group. Bars represent mean±SEM. * p< 0.05, **p< 0.01.