Research Paper Volume 13, Issue 2 pp 1692—1717

A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide, MOTS-c

Lack of a MOTS-c effect in female mice. 12 weeks old CD1 female mice fed a high fat diet were treated with WT MOTS-c and K14Q MOTS-c similarly to Figure 2A–2D (n = 8) for 12 days. (A) body weight, (B) fat mass, (C) lean mass, (D) food intake. Eight-weeks old female mice fed a HFD diet (n = 8-10) treated with WT and K14Q MOTS-c (0.5 mg/kg; IP; daily) for 21 days and assessed by a glucose tolerance test (GTT). Shown are (E) Blood glucose and (F) glucose AUC, during the GTT.

Figure 3. Lack of a MOTS-c effect in female mice. 12 weeks old CD1 female mice fed a high fat diet were treated with WT MOTS-c and K14Q MOTS-c similarly to Figure 2A2D (n = 8) for 12 days. (A) body weight, (B) fat mass, (C) lean mass, (D) food intake. Eight-weeks old female mice fed a HFD diet (n = 8-10) treated with WT and K14Q MOTS-c (0.5 mg/kg; IP; daily) for 21 days and assessed by a glucose tolerance test (GTT). Shown are (E) Blood glucose and (F) glucose AUC, during the GTT.