Research Paper Volume 13, Issue 2 pp 1692—1717

A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide, MOTS-c

The prevalence of type 2 diabetes in m.1382A>C polymorphism carriers. (A) Forest plot for meta-analysis (pooled random effects) on the prevalence of type 2 diabetes in males. Odds ratios are adjusted by age and BMI. Test for the pooled effect, Z = 2.86, p 2 = 0%, p = 0.84). (B) Forest plot for meta-analysis (pooled random effects) on the prevalence of type 2 diabetes in female. Odds ratios are adjusted by age and BMI. Test for the pooled effect, Z = -0.46, p = 0.64. Heterogeneity was insignificant (I2 = 33.6%, p = 0.22). In Japan Multi-Institutional Collaborative Cohort (J-MICC) study, m.1382A>C polymorphism carriers divided by tertile of physical activity in (C) males and (D) females. Activity was assessed by the degree of moderate-to-vigorous intensity physical activity (MVPA). In men only, sedentary levels of MVPA were associated with an increased risk of diabetes in the C allele. Cochran-Armitage trend test of m.1382 C allele for men, χ2 = 6.26, p = 0.012. Cochran-Armitage trend test of m.1382 A allele for females, χ2 = 0.03, p = 0.861.

Figure 5. The prevalence of type 2 diabetes in m.1382A>C polymorphism carriers. (A) Forest plot for meta-analysis (pooled random effects) on the prevalence of type 2 diabetes in males. Odds ratios are adjusted by age and BMI. Test for the pooled effect, Z = 2.86, p < 0.01. Heterogeneity was insignificant (I2 = 0%, p = 0.84). (B) Forest plot for meta-analysis (pooled random effects) on the prevalence of type 2 diabetes in female. Odds ratios are adjusted by age and BMI. Test for the pooled effect, Z = -0.46, p = 0.64. Heterogeneity was insignificant (I2 = 33.6%, p = 0.22). In Japan Multi-Institutional Collaborative Cohort (J-MICC) study, m.1382A>C polymorphism carriers divided by tertile of physical activity in (C) males and (D) females. Activity was assessed by the degree of moderate-to-vigorous intensity physical activity (MVPA). In men only, sedentary levels of MVPA were associated with an increased risk of diabetes in the C allele. Cochran-Armitage trend test of m.1382 C allele for men, χ2 = 6.26, p = 0.012. Cochran-Armitage trend test of m.1382 A allele for females, χ2 = 0.03, p = 0.861.