Research Paper Volume 13, Issue 5 pp 6724—6739

MiR-506 exerts antineoplastic effects on osteosarcoma cells via inhibition of the Skp2 oncoprotein

Overexpression of miR-506 inhibited cell motility. (A) Left: Migrative ability was evaluated by wound healing approach in osteosarcoma cells after miR-506 mimic treatment. Right: Quantitative results of migration. *pB) Left: Invasion was evaluated by Transwell assay in osteosarcoma cells treated with miR-506 mimics. Right: Quantitative results of invasion.

Figure 2. Overexpression of miR-506 inhibited cell motility. (A) Left: Migrative ability was evaluated by wound healing approach in osteosarcoma cells after miR-506 mimic treatment. Right: Quantitative results of migration. *p< 0.05, compared to control. (B) Left: Invasion was evaluated by Transwell assay in osteosarcoma cells treated with miR-506 mimics. Right: Quantitative results of invasion.