Research Paper Volume 13, Issue 2 pp 1718—1728

Effects of alpha-cyclodextrin on water transport, cell hydration and longevity

a-CD treatment can extend life span in C. elegans. (A) Kaplan-Meyer lifespan curve of control (untreated – blue curve) vs. a-CD-treated (0.05 w/v% - orange curve, 0.5 w/v% - green curve) animals. Animals treated with 0.05 w/v% a-CD live longer by 2 days on average than control. Both mean and maximum life spans become longer in response to treatment (see Supplementary Tables 1, 2). A higher concentration of a-CD (0.5 w/v%), however, does not lead to a longevity response. (B) a-CD at a working concentration of 0.1 w/v% slightly influences C. elegans life span. Kaplan-Meyer lifespan curves are shown. For statistics, see Supplementary Tables 1, 2.

Figure 4. a-CD treatment can extend life span in C. elegans. (A) Kaplan-Meyer lifespan curve of control (untreated – blue curve) vs. a-CD-treated (0.05 w/v% - orange curve, 0.5 w/v% - green curve) animals. Animals treated with 0.05 w/v% a-CD live longer by 2 days on average than control. Both mean and maximum life spans become longer in response to treatment (see Supplementary Tables 1, 2). A higher concentration of a-CD (0.5 w/v%), however, does not lead to a longevity response. (B) a-CD at a working concentration of 0.1 w/v% slightly influences C. elegans life span. Kaplan-Meyer lifespan curves are shown. For statistics, see Supplementary Tables 1, 2.