Figure 3. Exosomal miR-149-5p was considered as a biomarker of lung adenocarcinoma. (A) Upregulation of exosomal miR-149-5p in lung adenocarcinoma compared to healthy controls in GSE111803. (B) The transmission electron micrograph of A549 cells exosomes. (C) Western blot analyses for exosomal markers, CD63 and TSG101. (D) Upregulation of exosomal miR-149-5p in lung adenocarcinoma patients. (E) ROC curve analysis of exosomal miR-149-5p in lung adenocarcinoma. (F) The expression level of exosomal miR-149-5p in different clinical stage. (G) The univariate regression and multivariate regression analysis of exosomal miR-149-5p. LUAD: lung adenocarcinoma; AUC: area under curve; HR: hazard ratio; CI: Confidence Interval.