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Exosome-derived long non-coding RNA ZFAS1 controls cardiac fibrosis in chronic kidney disease

Exosome-lncRNA ZFAS1 regulated fibrosis in human cardiac fibroblasts. (A) Cell morphology detection. (B) RT-PCR assay was performed to measure the expression of Col1a1, Col3a1, MMP2, MMP9, α-SMA, and CTGF. (C) The expression level of Col1a1, TGF-β1, Fibronectin, α-SMA were assessed in HCFs. (D) The effect of exosome-lncRNA ZFAS1 on the wnt4/β-catenin signal pathway. *P

Figure 3. Exosome-lncRNA ZFAS1 regulated fibrosis in human cardiac fibroblasts. (A) Cell morphology detection. (B) RT-PCR assay was performed to measure the expression of Col1a1, Col3a1, MMP2, MMP9, α-SMA, and CTGF. (C) The expression level of Col1a1, TGF-β1, Fibronectin, α-SMA were assessed in HCFs. (D) The effect of exosome-lncRNA ZFAS1 on the wnt4/β-catenin signal pathway. *P<0.05.