Research Paper Advance Articles

Exosome-derived long non-coding RNA ZFAS1 controls cardiac fibrosis in chronic kidney disease

Exosome-lncRNA ZFAS1 aggravated cardiac fibrosis in CKD mice. (A) The cardiac function in mice was detected by echocardiography. (B) RT-PCR assay was performed to measure the expression of Col1a1, Col3a1, MMP2, MMP9, α-SMA, and CTGF. (C) The represented image of Masson. (D) The represented image of Immunohistochemistry for staining Fibronectin. (E) The expression level of Col1a1, TGF-β1, Fibronectin, α-SMA were assessed in heart tissues. (F) The effect of exosome-lncRNA ZFAS1 on the wnt4/β-catenin signal pathway. *P

Figure 4. Exosome-lncRNA ZFAS1 aggravated cardiac fibrosis in CKD mice. (A) The cardiac function in mice was detected by echocardiography. (B) RT-PCR assay was performed to measure the expression of Col1a1, Col3a1, MMP2, MMP9, α-SMA, and CTGF. (C) The represented image of Masson. (D) The represented image of Immunohistochemistry for staining Fibronectin. (E) The expression level of Col1a1, TGF-β1, Fibronectin, α-SMA were assessed in heart tissues. (F) The effect of exosome-lncRNA ZFAS1 on the wnt4/β-catenin signal pathway. *P <0.05 vs. sham, #P <0.05 vs. CKD.