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Exosome-derived long non-coding RNA ZFAS1 controls cardiac fibrosis in chronic kidney disease

Silencing of lncRNA ZFAS1 blocked cardiac fibrosis in HCFs. (A) RT-PCR assay was performed to measure the expression of Col1a1, Col3a1, MMP2, MMP9, α-SMA, and CTGF. (B) The expression level of Col1a1, TGF-β1, Fibronectin, α-SMA were assessed in HCFs after sh-ZFAS1 transfection. (C) The effect of lncRNA ZFAS1 on the wnt4/β-catenin signal pathway. *P

Figure 6. Silencing of lncRNA ZFAS1 blocked cardiac fibrosis in HCFs. (A) RT-PCR assay was performed to measure the expression of Col1a1, Col3a1, MMP2, MMP9, α-SMA, and CTGF. (B) The expression level of Col1a1, TGF-β1, Fibronectin, α-SMA were assessed in HCFs after sh-ZFAS1 transfection. (C) The effect of lncRNA ZFAS1 on the wnt4/β-catenin signal pathway. *P <0.05 vs. sh-NC.