Research Paper Volume 13, Issue 5 pp 7538—7548

SEDT2/METTL14-mediated m6A methylation awakening contributes to hypoxia-induced pulmonary arterial hypertension in mice

Generation and characterization of mice with smooth muscle cells specific knockout of SETD2. (A) The targeting strategy of mice with specific knockout of SETD2 in smooth muscle cells. (B) Western blotting was used to confirm the expression of SETD2 in smooth muscle cells from normal mice and SMCs SETD2 specific knockout mice.

Figure 1. Generation and characterization of mice with smooth muscle cells specific knockout of SETD2. (A) The targeting strategy of mice with specific knockout of SETD2 in smooth muscle cells. (B) Western blotting was used to confirm the expression of SETD2 in smooth muscle cells from normal mice and SMCs SETD2 specific knockout mice.