Research Paper Volume 13, Issue 5 pp 7538—7548

SEDT2/METTL14-mediated m6A methylation awakening contributes to hypoxia-induced pulmonary arterial hypertension in mice

SMCs specific SETD2 deficient attenuates pathological remodeling of pulmonary artery and right ventricular hypertrophy. (A) The right ventricular hypertrophy was evaluated by the RV/BW ratio (the ratio of the right ventricular mass to the sum of body masses) and RV/(L+S) ratio (the ratio of the right ventricular mass to the sum of the left ventricular and septal masses). (B) Haematoxylin and eosin (HE) staining and the analyzed PAMT ration of both small and medium pulmonary arteries were used to evaluate the pulmonary blood vessel remodeling during the course of PAH development. (C) Histochemical staining of SETD2 immunostaining was used to detect the SETD2 expression in lung blood vessels. All data were presented as Mean±SD (n=5). *PP

Figure 4. SMCs specific SETD2 deficient attenuates pathological remodeling of pulmonary artery and right ventricular hypertrophy. (A) The right ventricular hypertrophy was evaluated by the RV/BW ratio (the ratio of the right ventricular mass to the sum of body masses) and RV/(L+S) ratio (the ratio of the right ventricular mass to the sum of the left ventricular and septal masses). (B) Haematoxylin and eosin (HE) staining and the analyzed PAMT ration of both small and medium pulmonary arteries were used to evaluate the pulmonary blood vessel remodeling during the course of PAH development. (C) Histochemical staining of SETD2 immunostaining was used to detect the SETD2 expression in lung blood vessels. All data were presented as Mean±SD (n=5). *P<0.05, **P<0.01 vs. corresponding group.