Research Paper Volume 13, Issue 4 pp 4946—4961

Fibroblasts from different body parts exhibit distinct phenotypes in adult progeria Werner syndrome

Foot fibroblasts exhibited reduced proliferative capacity compared to that from the trunk in a telomere length-dependent manner. (A) Growth curves of the fibroblasts from the trunk and foot in two WS patients. (B) Telomere length quantification through Q-FISH. Data are median values ± interquartile range of each cell line. More than 150 cells for each cell line were analyzed. For statistical analysis, Mann Whitney test was performed (****pC) Representative image of telomere Q-FISH of WS1. Bar = 10 μm.

Figure 1. Foot fibroblasts exhibited reduced proliferative capacity compared to that from the trunk in a telomere length-dependent manner. (A) Growth curves of the fibroblasts from the trunk and foot in two WS patients. (B) Telomere length quantification through Q-FISH. Data are median values ± interquartile range of each cell line. More than 150 cells for each cell line were analyzed. For statistical analysis, Mann Whitney test was performed (****p<0.0001). (C) Representative image of telomere Q-FISH of WS1. Bar = 10 μm.