Research Paper Volume 13, Issue 4 pp 4946—4961

Fibroblasts from different body parts exhibit distinct phenotypes in adult progeria Werner syndrome

Transcriptome analysis showed distinct gene expression profiles between the trunk and foot fibroblasts. (A) Heatmap of differentially expressed genes between the trunk and foot. Cutoff: |log2(Foot/Trunk)| > 1 and FDR B) List of the top seven Gene Ontology (GO: biological process) terms and corresponding p values related to Figure 2A. (C) Differentially expressed genes specifically involved in embryonic development and mesenchymal cell differentiation. Data are means ± SEM of two patients (technically n=2 in each sample).

Figure 2. Transcriptome analysis showed distinct gene expression profiles between the trunk and foot fibroblasts. (A) Heatmap of differentially expressed genes between the trunk and foot. Cutoff: |log2(Foot/Trunk)| > 1 and FDR < 0.05. (B) List of the top seven Gene Ontology (GO: biological process) terms and corresponding p values related to Figure 2A. (C) Differentially expressed genes specifically involved in embryonic development and mesenchymal cell differentiation. Data are means ± SEM of two patients (technically n=2 in each sample).