Research Paper Volume 13, Issue 8 pp 11352—11362

Genetic effect of MTHFR C677T, A1298C, and A1793G polymorphisms on the age at onset, plasma homocysteine, and white matter lesions in Alzheimer's disease in the Chinese population

Correlations of AAO and homocysteine with APOE4, MTHFR C667T, A1298C, and A1793G genotypes in AD patients. (A) Correlation of AAO with APOE4, MTHFR C667T, A1298C, and A1793G genotypes in (a) AD (N = 721), (b) EOAD (N = 318), and (c) LOAD (N = 403). (B) Correlation of homocysteine with APOE4, MTHFR C667T, A1298C, and A1793G genotypes in AD (N = 121). Descriptive statistics were described as the mean ± standard deviation. Statistics performed by Kruskal-Wallis test, *p **p

Figure 1. Correlations of AAO and homocysteine with APOE4, MTHFR C667T, A1298C, and A1793G genotypes in AD patients. (A) Correlation of AAO with APOE4, MTHFR C667T, A1298C, and A1793G genotypes in (a) AD (N = 721), (b) EOAD (N = 318), and (c) LOAD (N = 403). (B) Correlation of homocysteine with APOE4, MTHFR C667T, A1298C, and A1793G genotypes in AD (N = 121). Descriptive statistics were described as the mean ± standard deviation. Statistics performed by Kruskal-Wallis test, *p < 0.05, **p < 0.01; ns: no statistical difference.