Research Paper Volume 13, Issue 8 pp 11491—11506

Comprehensive analysis of ferritin subunits expression and positive correlations with tumor-associated macrophages and T regulatory cells infiltration in most solid tumors

FTL and FTH1 levels were positively correlated with some of 47 distinct immune-related markers in 32 solid tumors. (A) FTL level was positively related to some immune-related markers, of which the most 2 were TIM-3 (26/32, 81.3%) and LAIR1 (26/32, 81.3%). Besides, FTL level was positively related to PD-1 in 14/32 cancers (43.8%), PD-L1 in 10/32 (31.3%), CTLA4 in 13/32 (40.6%), and LAG3 in 13/32 (40.6%). (B) FTH1 level was positively related to some immune-related markers, of which the most 2 were TIM-3 (20/32, 62.5%) and LAIR1 (19/32, 59.4%). Besides, FTH1 level was positively related to PD-1 in 4/32 (12.5%) cancers, PD-L1 in 9/32 (28.1%), CTLA4 in 7/32 (21.9%), and LAG3 in 2/32 (6.3%).

Figure 4. FTL and FTH1 levels were positively correlated with some of 47 distinct immune-related markers in 32 solid tumors. (A) FTL level was positively related to some immune-related markers, of which the most 2 were TIM-3 (26/32, 81.3%) and LAIR1 (26/32, 81.3%). Besides, FTL level was positively related to PD-1 in 14/32 cancers (43.8%), PD-L1 in 10/32 (31.3%), CTLA4 in 13/32 (40.6%), and LAG3 in 13/32 (40.6%). (B) FTH1 level was positively related to some immune-related markers, of which the most 2 were TIM-3 (20/32, 62.5%) and LAIR1 (19/32, 59.4%). Besides, FTH1 level was positively related to PD-1 in 4/32 (12.5%) cancers, PD-L1 in 9/32 (28.1%), CTLA4 in 7/32 (21.9%), and LAG3 in 2/32 (6.3%).