Research Paper Volume 13, Issue 10 pp 14015—14038

NUPR1 is a novel potential biomarker and confers resistance to sorafenib in clear cell renal cell carcinoma by increasing stemness and targeting the PTEN/AKT/mTOR pathway

NUPR1 promoted aggressive abilities of ccRCC in vivo. (A) Growth curves of subcutaneous xenografts in nude mice (n=5). (B) Photographs of nude mice and xenografts. (C) NUPR1 and Ki-67 expression were detected by IHC in xenografts sections. (*p p p

Figure 3. NUPR1 promoted aggressive abilities of ccRCC in vivo. (A) Growth curves of subcutaneous xenografts in nude mice (n=5). (B) Photographs of nude mice and xenografts. (C) NUPR1 and Ki-67 expression were detected by IHC in xenografts sections. (*p < 0.05, **p < 0.01, ***p < 0.001). ccRCC: clear cell renal cell carcinoma; IHC: Immunohistochemistry.