Research Paper Advance Articles

Overexpressed DEPDC1B contributes to the progression of hepatocellular carcinoma by CDK1

Potential mechanisms of DEPDC1B functions on HCC. (A–C) Bcl-2, Bcl-w, HSP27, HSP70, Livin, sTNF-R2, TNF-α, and TNF-β was significantly down-regulated in shDEPDC1B (PD) P-Akt, CDK6, Cyclin D1, and PIK3CA was down-regulated in shDEPDC1B group.

Figure 4. Potential mechanisms of DEPDC1B functions on HCC. (AC) Bcl-2, Bcl-w, HSP27, HSP70, Livin, sTNF-R2, TNF-α, and TNF-β was significantly down-regulated in shDEPDC1B (P<0.05). (D) P-Akt, CDK6, Cyclin D1, and PIK3CA was down-regulated in shDEPDC1B group.