Research Paper Volume 13, Issue 12 pp 15964—15989

Antrodia salmonea induces apoptosis and enhances cytoprotective autophagy in colon cancer cells

AS prevented AOM/DSS-induced tumor formation in ICR mice. Mice were injected intraperitoneally with a single dose (15 mg/kg) of AOM (the first week) followed by 3 times of 2% DSS given in the drinking water every two days (the second week). AS (150 and 300 mg/kg) was given oral administration every two days. Mice were sacrificed on 15 weeks after CAC induction. (A) The colon was removed and photographed. (B) Tumor numbers and (C) size were counted and calculated. Statistical significance was defined as ***p #p

Figure 13. AS prevented AOM/DSS-induced tumor formation in ICR mice. Mice were injected intraperitoneally with a single dose (15 mg/kg) of AOM (the first week) followed by 3 times of 2% DSS given in the drinking water every two days (the second week). AS (150 and 300 mg/kg) was given oral administration every two days. Mice were sacrificed on 15 weeks after CAC induction. (A) The colon was removed and photographed. (B) Tumor numbers and (C) size were counted and calculated. Statistical significance was defined as ***p < 0.001 compared with control or #p < 0.05 compared with AOM/DSS-treated cells.