Research Paper Volume 13, Issue 11 pp 15151—15163

Narciclasine attenuates sepsis-induced myocardial injury by modulating autophagy

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Figure 2.

Narciclasine attenuates LPS-induced myocardial dysfunction. (A) Echocardiographic analysis of LVEF, LVFS, IVSd, IVSs, LVIDs, LVIDd, LVPWd, and LVPWs after LPS challenge for 12 h. (B) The survival rates of LPS-injected mice throughout the 96-h study period. LVEF, left ventricular ejection fraction; LVFS, left ventricular fractional shortening; IVSd and IVSs, interventricular septal end diastole and end systole, respectively; LVIDd and LVIDs, left ventricular internal diameter end diastole and end systole, respectively; LVPWd and LVPWs, left ventricular posterior wall end diastole and end systole, respectively. n = 8 per group. The data are shown as the means ± SEM. *P < 0.05 vs. the PBS group. #P < 0.05 vs. the LPS group.