Research Paper Volume 13, Issue 11 pp 15151—15163

Narciclasine attenuates sepsis-induced myocardial injury by modulating autophagy

The autophagy inhibitor 3-MA and knockdown of ATG5 abrogates narciclasine-mediated protection against LPS-induced myocardial injury. (A–B) Echocardiographic analysis of the LVEF and LVFS in mouse hearts after LPS challenge for 12 h. (C–D) The survival rates of LPS-injected mice throughout the 96-h study period. n = 8 per group. The data are shown as the means ± SEM. *P #P

Figure 5. The autophagy inhibitor 3-MA and knockdown of ATG5 abrogates narciclasine-mediated protection against LPS-induced myocardial injury. (AB) Echocardiographic analysis of the LVEF and LVFS in mouse hearts after LPS challenge for 12 h. (CD) The survival rates of LPS-injected mice throughout the 96-h study period. n = 8 per group. The data are shown as the means ± SEM. *P < 0.05 vs. the Narc group. #P < 0.05 vs. the Narc+LPS group.