Research Paper Volume 13, Issue 11 pp 15444—15458

Alterations in the RTK/Ras/PI3K/AKT pathway serve as potential biomarkers for immunotherapy outcome of diffuse gliomas

The landscape of immunotherapy predictive biomarkers in association with RTK/Ras/PI3K/AKT pathway. It displayed that elevated TMB (A), CYT (C), and infiltrating CD8+ T cells (D), and decreased tumor purity (B) in the activated RTK/Ras/PI3K/AKT pathway.

Figure 2. The landscape of immunotherapy predictive biomarkers in association with RTK/Ras/PI3K/AKT pathway. It displayed that elevated TMB (A), CYT (C), and infiltrating CD8+ T cells (D), and decreased tumor purity (B) in the activated RTK/Ras/PI3K/AKT pathway.