Figure 8. Extensive crosstalk networks in human femoral head tissue cells. (A) Capacity for inter-cellular communication between osteoblastic lineage cells and other cells in human femoral head. The map quantifies the potential communication, but does not consider the anatomical location or boundaries of the cell type. The color of each line indicates the ligands expressed by the same color cell type. The lines connect to the cell clusters types that express the cognate receptors. The thickness of line is proportional to the number of ligands. The loop indicates autocrine circuits. The number indicates the quantity of ligand-receptor pairs in each inter-cellular link. (B) Detailed view of the ligands and cognate receptors between each cell type. (C) Overview of selected ligand-receptor interactions of osteoblastic lineage cells. Interaction score is indicated by circle size and color. Mono: monocyte; EC: endothelial cell; OBC: osteoblastic lineage cell; EPC: endothelial progenitor cell; RBC: red blood cell; PDC: plasmacytoid dendritic cell.