Research Paper Volume 13, Issue 12 pp 16043—16061

HMGA1 promotes gastric cancer growth and metastasis by transactivating SUZ12 and CCDC43 expression

SUZ12/CCDC43 is necessary for HMGA1-induced GC metastasis in vivo. (A) Whole-body fluorescence imaging of GC progression in mice (n = 3). Images of metastatic loci in the lungs by arrows. (B) Number of metastatic loci in lung was counted. ***, P C) H&E staining of lungs was performed in samples from mice. (D) MMP7 expression in the lung metastasis of GC was detected by IHC. (E) Expression of MMP7 in lung tumours derived from AGS cells was determined by qRT-PCR. **, P C, D).

Figure 6. SUZ12/CCDC43 is necessary for HMGA1-induced GC metastasis in vivo. (A) Whole-body fluorescence imaging of GC progression in mice (n = 3). Images of metastatic loci in the lungs by arrows. (B) Number of metastatic loci in lung was counted. ***, P < 0.01. (C) H&E staining of lungs was performed in samples from mice. (D) MMP7 expression in the lung metastasis of GC was detected by IHC. (E) Expression of MMP7 in lung tumours derived from AGS cells was determined by qRT-PCR. **, P < 0.05; ***, P < 0.01. Scale bars, 50 μm in (C, D).