Research Paper Advance Articles

Carbon nanotubes (CNT)-loaded ginsenosides Rb3 suppresses the PD-1/PD-L1 pathway in triple-negative breast cancer

Rg3-CNT decreases the PD-L1 upregulation induced by IFN-γ in TNBC cells. (A, B) The MDA-MB-231 and BT-549 cells were treated with IFN-γ (200 ng/mL). The expression of PD-L1 was analyzed by fluorescence-activated cell sorting (FACS) in the cells. (C, D) The MDA-MB-231 and BT-549 cells were treated with IFN-γ (200 ng/mL), or co-treated with IFN-γ (200 ng/mL) and Rg3-CNT (60 μg/ml). The expression of PD-L1 was analyzed by fluorescence-activated cell sorting (FACS) in the cells. Data are presented as mean ± SD. Statistic significant differences were indicated: ** P

Figure 3. Rg3-CNT decreases the PD-L1 upregulation induced by IFN-γ in TNBC cells. (A, B) The MDA-MB-231 and BT-549 cells were treated with IFN-γ (200 ng/mL). The expression of PD-L1 was analyzed by fluorescence-activated cell sorting (FACS) in the cells. (C, D) The MDA-MB-231 and BT-549 cells were treated with IFN-γ (200 ng/mL), or co-treated with IFN-γ (200 ng/mL) and Rg3-CNT (60 μg/ml). The expression of PD-L1 was analyzed by fluorescence-activated cell sorting (FACS) in the cells. Data are presented as mean ± SD. Statistic significant differences were indicated: ** P < 0.01.