Research Paper Volume 13, Issue 12 pp 16062—16071

PirB functions as an intrinsic suppressor in hippocampal neural stem cells

PirB knockout promotes NSC differentiation ability. (A–B) PirB knockout promotes the differentiation of NSCs into neurons. Tuj1 and MAP2 marks immature postmitotic neurons and mature neurons, respectively. PirB knockout promotes the differentiation of NSCs into (C) astrocytes and (D) oligodendrocytes. Means ± SEM, *P **P ***P t-test.

Figure 3. PirB knockout promotes NSC differentiation ability. (AB) PirB knockout promotes the differentiation of NSCs into neurons. Tuj1 and MAP2 marks immature postmitotic neurons and mature neurons, respectively. PirB knockout promotes the differentiation of NSCs into (C) astrocytes and (D) oligodendrocytes. Means ± SEM, *P < 0.05; **P < 0.01; ***P < 0.001 by the t-test.