Research Paper Volume 13, Issue 12 pp 16088—16104

High glucose exacerbates neuroinflammation and apoptosis at the intermediate stage after post-traumatic brain injury

Mechanistic diagram. HG exacerbated hippocampal injury following TBI, largely by disrupting the balance between pro- and anti-inflammatory factors and inducing apoptosis in hippocampal neurons. The MEK5/ERK5 pathway was found to participate in both of these processes.

Figure 8. Mechanistic diagram. HG exacerbated hippocampal injury following TBI, largely by disrupting the balance between pro- and anti-inflammatory factors and inducing apoptosis in hippocampal neurons. The MEK5/ERK5 pathway was found to participate in both of these processes.