Research Paper Advance Articles

Melatonin protects against focal cerebral ischemia-reperfusion injury in diabetic mice by ameliorating mitochondrial impairments: involvement of the Akt-SIRT3-SOD2 signaling pathway

Correlation between the Akt signaling and the SIRT3/SOD2 signaling in mediating the neuroprotective actions of melatonin. (A) Representative images for Akt phosphorylation, SIRT3 expression, and SOD2 acetylation detected by Western blot. (B–D) Quantitative analysis of the ratio of p-Akt/Akt, expression of SIRT3, and the ratio of ac-SOD2/SOD2. Data were presented as the mean ± SEM (n = 6). ap bp cp dp

Figure 8. Correlation between the Akt signaling and the SIRT3/SOD2 signaling in mediating the neuroprotective actions of melatonin. (A) Representative images for Akt phosphorylation, SIRT3 expression, and SOD2 acetylation detected by Western blot. (BD) Quantitative analysis of the ratio of p-Akt/Akt, expression of SIRT3, and the ratio of ac-SOD2/SOD2. Data were presented as the mean ± SEM (n = 6). ap < 0.05 vs. control group; bp < 0.05 vs. SIR+V group; cp < 0.05 vs. SIR+Mel group; dp < 0.05 vs. SIR+Mel+LY294002 group.