Research Paper Volume 13, Issue 11 pp 14829—14842

Effect of samul-tang on female fertility via RAS signaling pathway in ovaries of aged mice

Differentially expressed mRNAs involved in RAS signaling pathway. Fluorescence intensities indicating the expression levels of Fgfr2, Rasgrf1, Egf, Rasal1, Sch3, Nf1, Fgf13, Gng8, and Rasgrf2 in the ovaries of YC, OC, and OC+SM mice. (A) Aging-induced downregulated expression of Fgfr2, Rasgrf2 and Egf were restored with SM administration. (B) Aging-induced upregulated expression of Rasal1 and Sch3 were restored with SM administration. (C) Expression of Nf1, Fgf13, Gng8, and Rasgrf1 were changed by SM administration in OC mice. Data are presented as mean ± standard error of the mean. Statistical analysis was performed using the Student’s t-test. YC: 8-week-old control mice; OC: 40-week-old mice; OC+SM: 40-week-old mice orally administered Samul-tang.

Figure 5. Differentially expressed mRNAs involved in RAS signaling pathway. Fluorescence intensities indicating the expression levels of Fgfr2, Rasgrf1, Egf, Rasal1, Sch3, Nf1, Fgf13, Gng8, and Rasgrf2 in the ovaries of YC, OC, and OC+SM mice. (A) Aging-induced downregulated expression of Fgfr2, Rasgrf2 and Egf were restored with SM administration. (B) Aging-induced upregulated expression of Rasal1 and Sch3 were restored with SM administration. (C) Expression of Nf1, Fgf13, Gng8, and Rasgrf1 were changed by SM administration in OC mice. Data are presented as mean ± standard error of the mean. Statistical analysis was performed using the Student’s t-test. YC: 8-week-old control mice; OC: 40-week-old mice; OC+SM: 40-week-old mice orally administered Samul-tang.