Research Paper Volume 13, Issue 12 pp 16219—16228

Immunological discrepancy in aged mice facilitates skin allograft survival

A representative of CD4+, CD8+, regulatory T-cells (CD4+foxp3+), and MDSC (CD11b+Gr-1+) in young (A) and aged (B) mice. The frequency of CD4+ (16.5 ± 1.2% versus 14.6 ± 2.9%, p = 0.185), CD8+ (8.9 ± 0.7% versus 8.4 ± 1.6%, p = 0.324), native regulatory T-cells (1.0 ± 0.8% versus 0.4 ± 0.6%, p = 0.160) in aged and young mice was not different. However, the frequency of MDSC (CD11b+Gr-1+) in aged mice was higher than that in young mice (4.4 ± 1.4% versus 1.6 ± 1.1%, p = 0.026).

Figure 1. A representative of CD4+, CD8+, regulatory T-cells (CD4+foxp3+), and MDSC (CD11b+Gr-1+) in young (A) and aged (B) mice. The frequency of CD4+ (16.5 ± 1.2% versus 14.6 ± 2.9%, p = 0.185), CD8+ (8.9 ± 0.7% versus 8.4 ± 1.6%, p = 0.324), native regulatory T-cells (1.0 ± 0.8% versus 0.4 ± 0.6%, p = 0.160) in aged and young mice was not different. However, the frequency of MDSC (CD11b+Gr-1+) in aged mice was higher than that in young mice (4.4 ± 1.4% versus 1.6 ± 1.1%, p = 0.026).