Research Paper Volume 13, Issue 12 pp 16219—16228

Immunological discrepancy in aged mice facilitates skin allograft survival

Kaplan-Meier survival curve of skin allografts. Skin grafts from C3H mice were transplanted to young (n = 11) B10 mice, aged B10 mice (n = 10) and aged B10 mice (n = 10) fed with entinostat. The results showed that the skin allograft survival on young B10 mice was 11.9 ± 5.2 days and was prolonged to 19.7 ± 5.2 days on aged mice (p = 0.005). When the aged mice was fed with entinostat to inhibit MDSC, the survival of skin grafts was shorten to 13.5 ± 4.7 days, which was not different from the survival on young mice (p = 0.359).

Figure 6. Kaplan-Meier survival curve of skin allografts. Skin grafts from C3H mice were transplanted to young (n = 11) B10 mice, aged B10 mice (n = 10) and aged B10 mice (n = 10) fed with entinostat. The results showed that the skin allograft survival on young B10 mice was 11.9 ± 5.2 days and was prolonged to 19.7 ± 5.2 days on aged mice (p = 0.005). When the aged mice was fed with entinostat to inhibit MDSC, the survival of skin grafts was shorten to 13.5 ± 4.7 days, which was not different from the survival on young mice (p = 0.359).