Research Paper Volume 13, Issue 12 pp 16267—16286

Long non-coding RNA HCP5 functions as a sponge of miR-29b-3p and promotes cell growth and metastasis in hepatocellular carcinoma through upregulating DNMT3A

LncRNA HCP5 promotes the growth and migration of HCC in vivo. (A) Tumor growth curve suggesting that the knockdown of HCP5 results in lower tumor growth in vivo (**pB) Results of hematoxylin and eosin (HE) staining. (C) Immunohistochemistry demonstrating the expression of E-cadherin and vimentin between tissues transfected with sh-control and sh-HCP5. (D) Immunohistochemistry illustrating that the knockdown of HCP5 results in lower a proliferation rate in HCC tissue when compared to the control group.

Figure 3. LncRNA HCP5 promotes the growth and migration of HCC in vivo. (A) Tumor growth curve suggesting that the knockdown of HCP5 results in lower tumor growth in vivo (**p<0.01, ***p<0.001). (B) Results of hematoxylin and eosin (HE) staining. (C) Immunohistochemistry demonstrating the expression of E-cadherin and vimentin between tissues transfected with sh-control and sh-HCP5. (D) Immunohistochemistry illustrating that the knockdown of HCP5 results in lower a proliferation rate in HCC tissue when compared to the control group.