Research Paper Volume 13, Issue 14 pp 18191—18222

Formononetin relieves the facilitating effect of lncRNA AFAP1-AS1-miR-195/miR-545 axis on progression and chemo-resistance of triple-negative breast cancer

The mechanism map illustrated that lncRNA AFAP1-AS1 promoted triple-negative breast cancer (TNBC) progression and chemo-resistance by disturbing the interaction of miR-195 with Raf-1 and that of miR-545 with CDK4. However, formononetin antagonized TNBC malignancy by lessening the effect of lncRNA AFAP1-AS1-guided miR-545/CDK4 axis and miR-195/Raf-1 axis on TNBC cells.

Figure 8. The mechanism map illustrated that lncRNA AFAP1-AS1 promoted triple-negative breast cancer (TNBC) progression and chemo-resistance by disturbing the interaction of miR-195 with Raf-1 and that of miR-545 with CDK4. However, formononetin antagonized TNBC malignancy by lessening the effect of lncRNA AFAP1-AS1-guided miR-545/CDK4 axis and miR-195/Raf-1 axis on TNBC cells.