Volume 13, Issue 14

31 July, 2021
pp 17955—19079

About the Cover

The cover features Figure 10 " Overview of main benefits promoted by GTE and cocoa dietary supplementations on aging-associated changes in the neuromuscular system of C57BL/6JRj mice“ from Gras et al.

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Table of Contents

Editorials

Temporomandibular joint aging and potential therapies

Yueying Zhou, Ming Xu, Sumit Yadav,

https://doi.org/10.18632/aging.203332 pp 17955—17956

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Mitochondria as extracellular vesicle cargo in aging

Nicole Noren Hooten, Michele K. Evans,

https://doi.org/10.18632/aging.203358 pp 17957—17958

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The need for geriatric scales in glioblastoma

Marta Domenech, Ainhoa Hernandez, Carmen Balana,

https://doi.org/10.18632/aging.203370 pp 17959—17960

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Research Papers

COVID-19
Two novel nomograms based on inflammatory cytokines or lymphocyte subsets to differentially diagnose severe or critical and Non-Severe COVID-19

Zhijun Li, Nan Jiang, Xinwei Li, Bo Yang, Mengdi Jin, Yaoyao Sun, Yang He, Yang Liu, Yueying Wang, Daoyuan Si, Piyong Ma, Jinnan Zhang, Tianji Liu, Qiong Yu,

https://doi.org/10.18632/aging.203307 pp 17961—17977

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Prognoses and genomic analyses of proteasome 26S subunit, ATPase (PSMC) family genes in clinical breast cancer

Tzu-Jen Kao, Chung-Che Wu, Nam Nhut Phan, Yen-Hsi Liu, Hoang Dang Khoa Ta, Gangga Anuraga, Yung-Fu Wu, Kuen-Haur Lee, Jian-Ying Chuang, Chih-Yang Wang,

https://doi.org/10.18632/aging.203345 pp 17970

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HDAC2 and 7 down-regulation induces senescence in dermal fibroblasts

Céline Warnon, Karim Bouhjar, Noëlle Ninane, Mathilde Verhoyen, Antoine Fattaccioli, Maude Fransolet, Catherine Lambert de Rouvroit, Yves Poumay, Géraldine Piel, Denis Mottet, Florence Debacq-Chainiaux,

https://doi.org/10.18632/aging.203304 pp 17978—18005

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Implication of integrin α2β1 in senescence of SK-Mel-147 human melanoma cells

Nadezhda I. Kozlova, Galina E. Morozevich, Albert E. Berman,

https://doi.org/10.18632/aging.203309 pp 18006—18017

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GAS6 ameliorates advanced age-associated meiotic defects in mouse oocytes by modulating mitochondrial function

Kyeoung-Hwa Kim, Eun-Young Kim, Kyung-Ah Lee,

https://doi.org/10.18632/aging.203328 pp 18018—18032

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β-amyloid monomers drive up neuronal aerobic glycolysis in response to energy stressors

Rosa Santangelo, Maria Laura Giuffrida, Cristina Satriano, Marianna Flora Tomasello, Stefania Zimbone, Agata Copani,

https://doi.org/10.18632/aging.203330 pp 18033—18050

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Beneficial effects of dietary supplementation with green tea catechins and cocoa flavanols on aging-related regressive changes in the mouse neuromuscular system

Sílvia Gras, Alba Blasco, Guillem Mòdol-Caballero, Olga Tarabal, Anna Casanovas, Lídia Piedrafita, Alejandro Barranco, Tapas Das, Ricardo Rueda, Suzette L. Pereira, Xavier Navarro, Josep E. Esquerda, Jordi Calderó,

https://doi.org/10.18632/aging.203336 pp 18051—18093

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Subclinical atherosclerosis and immune activation in young HIV-infected patients with telomere shortening

María José Alcaraz, Antonia Alcaraz, Raúl Teruel-Montoya, José A. Campillo, Alejandro de la Torre, Ángeles Muñoz, Cristina Tomás, Gabriel Puche, Carlos Báguena, Alfredo Cano, Alfredo Minguela, Enrique Bernal,

https://doi.org/10.18632/aging.203350 pp 18094—18105

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Autophagy inhibition reinforces stemness together with exit from dormancy of polydisperse glioblastoma stem cells

Aude Brunel, Sophie Hombourger, Elodie Barthout, Serge Battu, Donat Kögel, Patrick Antonietti, Elise Deluche, Sofiane Saada, Stéphanie Durand, Fabrice Lalloué, Marie-Odile Jauberteau, Gaëlle Begaud, Barbara Bessette, Mireille Verdier,

https://doi.org/10.18632/aging.203362 pp 18106—18130

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Grape skin extract modulates neuronal stem cell proliferation and improves spatial learning in senescence-accelerated prone 8 mice

Kazunori Sasaki, Noelia Geribaldi-Doldan, Francis G. Szele, Hiroko Isoda,

https://doi.org/10.18632/aging.203373 pp 18131—18149

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Integration of segmented regression analysis with weighted gene correlation network analysis identifies genes whose expression is remodeled throughout physiological aging in mouse tissues

Margarida Ferreira, Stephany Francisco, Ana R. Soares, Ana Nobre, Miguel Pinheiro, Andreia Reis, Sonya Neto, Ana João Rodrigues, Nuno Sousa, Gabriela Moura, Manuel A. S. Santos,

https://doi.org/10.18632/aging.203379 pp 18150—18190

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Formononetin relieves the facilitating effect of lncRNA AFAP1-AS1-miR-195/miR-545 axis on progression and chemo-resistance of triple-negative breast cancer

Jingjing Wu, Wen Xu, Lina Ma, Jiayu Sheng, Meina Ye, Hao Chen, Yuzhu Zhang, Bing Wang, Mingjuan Liao, Tian Meng, Yue Zhou, Hongfeng Chen,

https://doi.org/10.18632/aging.203156 pp 18191—18222

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Combination of rapamycin and SAHA enhanced radiosensitization by inducing autophagy and acetylation in NSCLC

Yong Wang, Fen Liu, Chen Fang, Liyao Xu, Lin Chen, Zeyao Xu, Jiaquan Chen, Wei Peng, Biqi Fu, Yong Li,

https://doi.org/10.18632/aging.203226 pp 18223—18237

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Integrated analysis of m⁶A mRNA methylation in rats with monocrotaline-induced pulmonary arterial hypertension

Yunhong Zeng, Ting Huang, Wanyun Zuo, Dan Wang, Yonghui Xie, Xun Wang, Zhenghui Xiao, Zhi Chen, Qiming Liu, Na Liu, Yunbin Xiao,

https://doi.org/10.18632/aging.203230 pp 18238—18256

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The lncRNA H19/miR-541-3p/Wnt/β-catenin axis plays a vital role in melatonin-mediated osteogenic differentiation of bone marrow mesenchymal stem cells

Hui Han, Tingyu Tian, Guoqian Huang, Dalu Li, Shimao Yang,

https://doi.org/10.18632/aging.203267 pp 18257—18273

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Predictive value of inflammation-based Glasgow prognostic score, platelet-lymphocyte ratio, and global registry of acute coronary events score for major cardiovascular and cerebrovascular events during hospitalization in patients with acute myocardial infarction

Xiaoqun Xu, Long Cai, Tielong Chen, Shibiao Ding, Fengwei Zhang, Beibei Gao, Houyong Zhu, Jinyu Huang,

https://doi.org/10.18632/aging.203273 pp 18274—18286

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Albiflorin alleviates cognitive dysfunction in STZ-induced rats

Xiaojun Ma, Min Song, Yushan Yan, Gaofei Ren, Jingwen Hou, Guijun Qin, Wang Wang, Zhizhen Li,

https://doi.org/10.18632/aging.203274 pp 18287—18297

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NUDCD1 knockdown inhibits the proliferation, migration, and invasion of pancreatic cancer via the EMT process

Chunling Shi, Min Weng, Hengyue Zhu, Yangyang Guo, Dongdong Xu, Hairu Jin, Binshuang Wei, Zhensheng Cao,

https://doi.org/10.18632/aging.203276 pp 18298—18309

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BMI1 activates P-glycoprotein via transcription repression of miR-3682-3p and enhances chemoresistance of bladder cancer cell

Ming-Kun Chen, Jun-Hao Zhou, Peng Wang, Yun-lin Ye, Yang Liu, Jia-Wei Zhou, Zi-Jian Chen, Jian-Kun Yang, De-Ying Liao, Zhi-Jian Liang, Xiao Xie, Qi-Zhao Zhou, Kang-Yi Xue, Wen-Bin Guo, Ming Xia, Ji-Ming Bao, Cheng Yang, Hai-Feng Duan, Hong-Yi Wang, Zhi-Peng Huang, Zi-Ke Qin, Cun-Dong Liu,

https://doi.org/10.18632/aging.203277 pp 18310—18330

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Prediction of pregnancy outcome in fresh in vitro fertilization/intracytoplasmic sperm injection treatment in patients with poor ovarian reserve

Ying Chen, AiQin Niu, XingMei Feng, YaLi Zhang, Fei Li,

https://doi.org/10.18632/aging.203282 pp 18331—18339

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CircSPIDR acts as a tumour suppressor in cervical adenocarcinoma by sponging miR-431-5p and regulating SORCS1 and CUBN expression

Junfen Xu, Weiguo Lu,

https://doi.org/10.18632/aging.203283 pp 18340—18359

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Aberrant expression of WDR4 affects the clinical significance of cancer immunity in pan-cancer

Hanqian Zeng, Shiwen Xu, Erjie Xia, Suzita Hirachan, Adheesh Bhandari, Yanyan Shen,

https://doi.org/10.18632/aging.203284 pp 18360—18375

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Association of a composite score of relative grip strength and timed up and go test with incident type 2 diabetes mellitus: Guangzhou Biobank Cohort Study

Xue Liang, Chao Qiang Jiang, Wei Sen Zhang, Feng Zhu, Ya Li Jin, Kar Keung Cheng, Tai Hing Lam, Lin Xu,

https://doi.org/10.18632/aging.203285 pp 18376—18391

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Curcumol may alleviate psoriasis-like inflammation by inhibiting keratinocyte proliferation and inflammatory gene expression via JAK1/STAT3 signaling

Mingfen Lv, Junyi Shao, Fan Jiang, Jingjing Liu,

https://doi.org/10.18632/aging.203287 pp 18392—18403

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Expression mode and prognostic value of FXYD family members in colon cancer

Ming Jin, Hui Zhang, Jun Yang, Zhen Zheng, Kaitai Liu,

https://doi.org/10.18632/aging.203290 pp 18404—18422

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Yiqi Jiemin decoction alleviates allergic rhinitis in a guinea pig model by suppressing inflammation, restoring Th1/Th2 balance, and improving cellular metabolism

Zhanfeng Yan, Lili Liu, Jingjing Yuan, Lulu Jiao, Mo Zhou, Jinfeng Liu, Xiaohui Wen, Siming Liu, Pengpeng Hao, Jianhua Liu, Wei Wu,

https://doi.org/10.18632/aging.203292 pp 18423—18441

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An interactive nomogram based on clinical and molecular signatures to predict prognosis in multiple myeloma patients

Linxin Liu, Jian Qu, Yuxin Dai, Tingting Qi, Xinqi Teng, Guohua Li, Qiang Qu,

https://doi.org/10.18632/aging.203294 pp 18442—18463

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Fibroblastic galectin-1-fostered invasion and metastasis are mediated by TGF-β1-induced epithelial-mesenchymal transition in gastric cancer

Xiaolan You, Jian Wu, Xiaojun Zhao, Xingyu Jiang, Wenxuan Tao, Zhiyi Chen, Chuanjiang Huang, Tingrui Zheng, Xianhe Shen,

https://doi.org/10.18632/aging.203295 pp 18464—18481

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ZC3HAV1 promotes the proliferation and metastasis via regulating KRAS in pancreatic cancer

Wei Huang, Hao Hua, Guoliang Xiao, Xianjin Yang, Qin Yang, Lu Jin,

https://doi.org/10.18632/aging.203296 pp 18482—18497

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Exosomal miRNA-205 promotes breast cancer chemoresistance and tumorigenesis through E2F1

Yan Zhao, Li-Jun Jin, Xiao-Yu Zhang,

https://doi.org/10.18632/aging.203298 pp 18498—18514

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Agomelatine prevents angiotensin II-induced endothelial and mononuclear cell adhesion

Najiao Hong, Zhirong Ye, Yongjun Lin, Wensen Liu, Na Xu, Yan Wang,

https://doi.org/10.18632/aging.203299 pp 18515—18526

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LncRNA CCAT1 promotes prostate cancer cells proliferation, migration, and invasion through regulation of miR-490-3p/FRAT1 axis

Xiaowei Cai, Yiheng Dai, Peng Gao, Guanyu Ren, Dingcai Cheng, Bo Wang, Yi Wang, Jiang Yu, Yiheng Du, Xizhi Wang, Boxin Xue,

https://doi.org/10.18632/aging.203300 pp 18527—18544

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The anti-dysenteric drug fraxetin enhances anti-tumor efficacy of gemcitabine and suppresses pancreatic cancer development by antagonizing STAT3 activation

Yangyang Guo, Yanyi Xiao, Hangcheng Guo, Hengyue Zhu, Dong Chen, Jilong Wang, Junjie Deng, Junjie Lan, Xiaodong Liu, Qiyu Zhang, Yongheng Bai,

https://doi.org/10.18632/aging.203301 pp 18545—18563

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Chocolate consumption and all-cause and cause-specific mortality in a US population: a post hoc analysis of the PLCO cancer screening trial

Guo-Chao Zhong, Tian-Yang Hu, Peng-Fei Yang, Yang Peng, Jing-Jing Wu, Wei-Ping Sun, Long Cheng, Chun-Rui Wang,

https://doi.org/10.18632/aging.203302 pp 18564—18585

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Circular RNA circSP3 promotes hepatocellular carcinoma growth by sponging microRNA-198 and upregulating cyclin-dependent kinase 4

Molin Li, Hang Chen, Lulu Xia, Ping Huang,

https://doi.org/10.18632/aging.203303 pp 18586—18605

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Obesity increases neuropathic pain via the AMPK-ERK-NOX4 pathway in rats

Chang-Ning Fu, Hui Wei, Wen-Shuang Gao, Sha-Sha Song, Shou-Wei Yue, Yu-Juan Qu,

https://doi.org/10.18632/aging.203305 pp 18606—18619

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Interleukin-2 inducible T-cell kinase: a potential prognostic biomarker and tumor microenvironment remodeling indicator for hepatocellular carcinoma

Binhua Pan, Modan Yang, Xuyong Wei, Wangyao Li, Kun Wang, Mengfan Yang, Di Lu, Rui Wang, Beini Cen, Xiao Xu,

https://doi.org/10.18632/aging.203306 pp 18620—18644

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A nomogram for predicting late radiation-induced xerostomia among locoregionally advanced nasopharyngeal carcinoma in intensity modulated radiation therapy era

Kaixuan Yang, Wenji Xie, Xiangbin Zhang, Yu Wang, Arthur Shou, Qiang Wang, Jiangfang Tian, Jiangping Yang, Guangjun Li,

https://doi.org/10.18632/aging.203308 pp 18645—18657

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LncRNA AC079630.4 expression associated with the progression and prognosis in lung cancer

Li-Fang Wang, Li-Ping Wu, Jian-Dong Wen,

https://doi.org/10.18632/aging.203310 pp 18658—18668

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Plasma metabolites changes in male heroin addicts during acute and protracted withdrawal

Yong Zhou, Zhenrong Xie, Zunyue Zhang, Jiqing Yang, Minghui Chen, Fengrong Chen, Yuru Ma, Cheng Chen, Qingyan Peng, Lei Zou, Jianyuan Gao, Yu Xu, Yiqun Kuang, Mei Zhu, Dingyun You, Juehua Yu, Kunhua Wang,

https://doi.org/10.18632/aging.203311 pp 18669—18688

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Catalpol enhanced physical exercise-mediated brain functional improvement in post-traumatic stress disorder model via promoting adult hippocampal neurogenesis

Lina Sun, Weiwei Zhang, Ruiqi Ye, Lei Liu, Lili Jiang, Chao Xi,

https://doi.org/10.18632/aging.203313 pp 18689—18700

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Development and validation of a novel epigenetic-related prognostic signature and candidate drugs for patients with lung adenocarcinoma

Zhihao Wang, Kidane Siele Embaye, Qing Yang, Lingzhi Qin, Chao Zhang, Liwei Liu, Xiaoqian Zhan, Fengdi Zhang, Xi Wang, Shenghui Qin,

https://doi.org/10.18632/aging.203315 pp 18701—18717

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Endothelial microparticle-associated protein disulfide isomerase increases platelet activation in diabetic coronary heart disease

Xiao-Di Sun, Lu Han, Hong-Tao Lan, Ran-Ran Qin, Ming Song, Wei Zhang, Ming Zhong, Zhi-Hao Wang,

https://doi.org/10.18632/aging.203316 pp 18718—18739

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MicroRNA-106b-5p inhibits growth and progression of lung adenocarcinoma cells by downregulating IGSF10

Bo Ling, Xianjiu Liao, Qiang Tang, Guangbin Ye, Xiaoyun Bin, Jianchu Wang, Yaqin Pang, Guangzi Qi,

https://doi.org/10.18632/aging.203318 pp 18740—18756

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Curcumin in combination with homoharringtonine suppresses lymphoma cell growth by inhibiting the TGF-β/Smad3 signaling pathway

Yu Zhang, Jingjing Xiang, Ni Zhu, Hangping Ge, Xianfu Sheng, Shu Deng, Junfa Chen, Lihong Yu, Yan Zhou, Jianping Shen,

https://doi.org/10.18632/aging.203319 pp 18757—18768

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An association study in the Taiwan Biobank elicits three novel candidates for cognitive aging in old adults: NCAM1, TTC12 and ZBTB20

Eugene Lin, Po-Hsiu Kuo, Wan-Yu Lin, Yu-Li Liu, Albert C. Yang, Shih-Jen Tsai,

https://doi.org/10.18632/aging.203321 pp 18769—18788

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Identification of prognostic long non-coding RNA signature with potential drugs in hepatocellular carcinoma

Fengjie Hao, Nan Wang, Xiang Wang, Yongjun Chen, Junqing Wang,

https://doi.org/10.18632/aging.203322 pp 18789—18805

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An immune-related lncRNA signature for the prognosis of pancreatic adenocarcinoma

Bing Qi, Han Liu, Qi Zhou, Li Ji, Xueying Shi, Yushan Wei, Yajun Gu, Akio Mizushima, Shilin Xia,

https://doi.org/10.18632/aging.203323 pp 18806—18826

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Programmed cell death-ligand 1 expression predicts poor treatment response and prognostic value in esophageal squamous cell carcinoma patients without esophagectomy

Fang Zhang, Xiuyuan Zhu, Qi Zhang, Ping Zhou, Liang Hao,

https://doi.org/10.18632/aging.203326 pp 18827—18838

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Association between carotid artery perivascular fat density and cerebral small vessel disease

Dan-Hong Zhang, Jiao-Lei Jin, Cheng-Fei Zhu, Qiu-Yue Chen, Xin-Wei He,

https://doi.org/10.18632/aging.203327 pp 18839—18851

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Regulation of the IGF1 signaling pathway is involved in idiopathic pulmonary fibrosis induced by alveolar epithelial cell senescence and core fucosylation

Wei Sun, Xiaoyan Jing, Xiaoyu Yang, Hui Huang, Qun Luo, Shu Xia, Ping Wang, Na Wang, Qian Zhang, Jian Guo, Zuojun Xu,

https://doi.org/10.18632/aging.203335 pp 18852—18869

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Atorvastatin attenuates intermittent hypoxia-induced myocardial oxidative stress in a mouse obstructive sleep apnea model

Xiao-Bin Zhang, Hui-Juan Cheng, Ya-Ting Yuan, Yan Chen, Yi-Yuan Chen, Kam Yu Chiu, Hui-Qing Zeng,

https://doi.org/10.18632/aging.203339 pp 18870—18878

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Myeloid DJ-1 deficiency protects acetaminophen-induced acute liver injury through decreasing inflammatory response

Bingrui Wang, Jichang Li, Junzhe Jiao, Min Xu, Yichun Luo, Fang Wang, Qiang Xia, Yueqiu Gao, Yu Feng, Xiaoni Kong, Xuehua Sun,

https://doi.org/10.18632/aging.203340 pp 18879—18893

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Prevalence of allergen-specific IgE in southern China: a multicenter research

Xue’an Wang, Long Zhou, Guixi Wei, Hui Zhang, Bin Yang,

https://doi.org/10.18632/aging.203341 pp 18894—18911

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Normal-sized basal ganglia perivascular space related to motor phenotype in Parkinson freezers

Wen Lv, Yumei Yue, Ting Shen, Xingyue Hu, Lili Chen, Fei Xie, Wenying Zhang, Baorong Zhang, Yaxing Gui, Hsin-Yi Lai, Fang Ba,

https://doi.org/10.18632/aging.203343 pp 18912—18923

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MicroRNA-1252-5p, regulated by Myb, inhibits invasion and epithelial-mesenchymal transition of pancreatic cancer cells by targeting NEDD9

Yuzheng Xue, Tielong Wu, Yingyue Sheng, Yao Zhong, Benshun Hu, Chuanqing Bao,

https://doi.org/10.18632/aging.203344 pp 18924—18945

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CircRNA circFOXK2 facilitates oncogenesis in breast cancer via IGF2BP3/miR-370 axis

Wei Zhang, Hui Liu, Junjie Jiang, Yunyun Yang, Wenjie Wang, Zhengyan Jia,

https://doi.org/10.18632/aging.203347 pp 18978—18992

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A network pharmacology approach to uncover the key ingredients in Ginkgo Folium and their anti-Alzheimer’s disease mechanisms

Peng Zeng, Meng Fang, Han Zhao, Jing Guo,

https://doi.org/10.18632/aging.203348 pp 18993—19012

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Glucagon-like peptide-1 attenuated carboxymethyl lysine induced neuronal apoptosis via peroxisome proliferation activated receptor-γ

Haoqiang Zhang, Bing Song, Wenwen Zhu, Lili Liu, Xiqiao He, Zheng Wang, Ke An, Wuyou Cao, Jijing Shi, Shaohua Wang,

https://doi.org/10.18632/aging.203351 pp 19013—19027

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Development and validation of prognostic model based on the analysis of autophagy-related genes in colon cancer

Yongfeng Wang, Kaili Lin, Tianchun Xu, Liuli Wang, Liangyin Fu, Guangming Zhang, Jing Ai, Yajun Jiao, Rongrong Zhu, Xiaoyong Han, Hui Cai,

https://doi.org/10.18632/aging.203352 pp 19028—19047

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Combined treatment with C16 peptide and angiopoietin-1 confers neuroprotection and reduces inflammation in 3-nitropropionic acid-induced dystonia mice

Xiao-Xiao Fu, Hua-Ying Cai, Hong Jiang, Shu Han,

https://doi.org/10.18632/aging.203354 pp 19048—19063

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Type I collagen promotes tumor progression of integrin β1 positive gastric cancer through a BCL9L/β-catenin signaling pathway

Yalei Lv, Yujie Shan, Lina Song, Yufei Zhao, Ruixue Lai, Junyan Su, Xiaoyun Zhang,

https://doi.org/10.18632/aging.203355 pp 19064—19076

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Corrections

Correction for: Suppressing the KIF20A/NUAK1/Nrf2/GPX4 signaling pathway induces ferroptosis and enhances the sensitivity of colorectal cancer to oxaliplatin

Changshun Yang, Yu Zhang, Shengtao Lin, Yi Liu, Weihua Li,

https://doi.org/10.18632/aging.203382 pp 19077

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Correction for: Silencing of long non-coding RNA H19 downregulates CTCF to protect against atherosclerosis by upregulating PKD1 expression in ApoE knockout mice

Yongyao Yang, Feng Tang, Fang Wei, Long Yang, Chunyan Kuang, Hongming Zhang, Jiusheng Deng, Qiang Wu,

https://doi.org/10.18632/aging.203391 pp 19078—19079

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