Research Paper Volume 13, Issue 14 pp 18894—18911
Prevalence of allergen-specific IgE in southern China: a multicenter research
- 1 Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China
- 2 Department of Laboratory Medicine, Chongqing University Sanxia Hospital, Chongqing 404000, China
- 3 Department of Laboratory Medicine, Liuzhou People's Hospital, Liuzhou 545000, China
- 4 Department of Laboratory Medicine, Shenzhen Second People's Hospital, Shenzhen 518048, China
Received: October 19, 2020 Accepted: June 29, 2021 Published: July 22, 2021https://doi.org/10.18632/aging.203341
How to Cite
Copyright: © 2021 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Identifying allergen distribution is meaningful and significant for effective diagnosis and treatment of allergic diseases. This study compared the allergen sensitivity in four southern China cities. We enrolled 55,432 participants (27,408 male, 28,024 female) between 2007 and 2019. The allergen-specific IgE levels were compared by the χ2 test. The five prevalent sensitivities were for mite mix (10,985, 19.82%), cockroach (4,860, 8.77%), crab (4,450, 8.03%), fish mix (3,874, 6.99%), and house dust (3,486, 6.29%). Almost all allergen sensitivities decreased with age, particularly from infant to middle aged participants (p < 0.05). An exception was Shenzhen, where food allergen positive rates remained constant in all age groups studied. The proportion of male sensitive to at least one food allergen (OR 1.130; 95% CI 1.088–1.174, p < 0.0025) or aeroallergen (OR, 1.117; 95% CI, 1.078–1.158, p < 0.0025) was higher than female in all four cities. Except for dog dander and tree mix, all aeroallergens differed significantly between seasons (p < 0.05). Liuzhou had the highest rates of food allergen- and aeroallergen-positive participants. The allergen-specific IgE distribution differed among the studied cities, with significant seasonal differences. Young age, male sex, and aeroallergens were risk factors for allergic disease.